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. 2018 Apr 18;8:6205. doi: 10.1038/s41598-018-24425-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MSCs pretreated with S100A8/A9 reveal a distinct transcriptome signature with impact on enhanced tissue repair. (a) Volcano plot representative of the entire gene expression data (untreated MSCs versus MSCs treated with S100A8/A9 for 6 h (left) and 24 h (right) were studied by DEseq. 2 analysis tool, where the log₁₀ P-value (FDR <0.5) of each gene is plotted against log ₂ fold for that gene. Differentially expressed (DE) genes (FDR <5%) and fold change (mean >1.5) are highlighted either in blue as upregulated or highlighted in red as downregulated. The non-significant genes which (FDR >5%) are highlighted in black. (b) Pathway analysis was done on the DE genes (log₂-fold change >0.6 and FDR <5%) employing iPathwayGuide analysis tool that uses two types of evidence: the over-representation on the horizontal axis (pORA) and the perturbation on the vertical axis (pAcc). Significant pathways with (FDR <5%) are shown in red, whereas non-significant are in black. The size of the circle is proportional to the number of genes in that pathway.