Table 3.
Plasmodium falciparum strains in this study.
| Strain | Source: BEI Resources | Resistance traits | IC50/nM |
|---|---|---|---|
| CamWT_C580Y | MRA-1251 | artemisinin | ND |
| Dd2 | MRA-150 | chloroquine, pyrimethamine, mefloquine | 87.8 [41.6–185.5] (chloroquine) |
| GB4 | MRA-925 | chloroquine | >12,500 (chloroquine) |
| NF54 | MRA-1000 | drug sensitive | 7.8 [1.8–34.4] (chloroquine) |
| SB1-A6 | MRA-1002 | cytochrome bc1 inhibitors (e.g. atovaquone)44 | 4065 [888–18613] (atovaquone) |
IC50 for a representative drug is indicated together with the 95% confidence interval returned after fitting a curve to the normalized data using the least squares method with variable slope.