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. 2018 Apr 18;9:1537. doi: 10.1038/s41467-018-03904-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Dynamic deposition of H3.3 during cellular reprogramming. a Average distribution of H3.3 peaks on the indicated genomic regions during cellular reprogramming. b PCA of H3.3 ChIP-Seq libraries at the indicated time-points. c–f Average enrichment profile of H3.3 reads, belonging to the libraries at the indicated time-points, around the genebodies of Cluster I (c), II (d), III (e) and IV genes (f). The y-axis represents average normalized number of fragments mapping to the corresponding regions indicated in the x-axis. g UCSC screenshot of the dynamic chromatin accessibility, gene expression and enrichment of H3.3 on Adcy7 (Cluster I gene) during reprogramming. h UCSC screenshot demonstrating the dynamic chromatin accessibility, gene expression and enrichment of H3.3 on Terf2 (Cluster III gene) during reprogramming