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. 2018 Apr 18;8:6153. doi: 10.1038/s41598-018-23844-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NDAPS1 manipulated gut microbiota in preexisting obese mice after dieting. NDAPS1 manipulated the abundance of specific bacteria at the (a) family, (b) genus and (c) species level. (d,e) LEfSe comparison of gut microbiota between HFW0, HFW4, NDS and NDAPS1 groups. n = 5 per group. The data are expressed as the mean ± SD. The nonparametric Wilcoxon signed rank test for paired data and Mann-Whitney U test for unpaired data (NDS vs. NDAPS1) were used. *P < 0.05, **P < 0.01, ***P < 0.001.