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. 2018 Apr 18;8:6201. doi: 10.1038/s41598-018-24356-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fluorescence micrographs of HIF-1α expression and distribution of EMBP in nasal mucosal tissue. (A) Confocal images show colocalization of HIF-1α and EMBP (black arrows) in nasal mucosal tissue from control subjects and patients with CRSsNP, a patient with CRSwNP, and a NP sample. White arrowheads indicate EMBP-positive and arrows show HIF-1α-positive cells. Cell nuclei were counterstained by DAPI (4′,6-diamidino-2-phenylindole). (B–D) Distribution of eosinophils and percentage of HIF-1α-positive cells in nasal mucosal tissue. The number of HIF-1α- positive cells was considerably higher in the NP tissues of the CRSwNP group compared to the other groups. Data are expressed as the means ± SD. *P < 0.05, **P < 0.01. Mann-Whitney U test. Scale bar = 20 μm.