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. 2018 Apr 18;8:6201. doi: 10.1038/s41598-018-24356-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nasal polyp burden is reduced in the wogonin-treated group. (A) Protocol for the development of chronic eosinophilic rhinosinusitis with nasal polyps in mice. Alum, Aluminum hydroxide; i.p., intraperitoneal injection; i.n., intranasal instillation. (B) and (C) Photographs of representative nasal polypoid lesions (arrows) stained with hematoxylin and eosin (original magnification ×1.25). Nasal polypoid lesions were detected in Groups B, C, and D. Numbers of nasal polyp-like lesions were expressed as the total number per coronal section. The numbers of polyp-like lesions were reduced in Groups C and D compared with that in Group B. The black box indicates the magnified area. Data are expressed as the means ± SD. *P < 0.05, **P < 0.01. Mann-Whitney U test. Scale bar = 20 μm.