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. 2018 Apr 18;9(5):440. doi: 10.1038/s41419-018-0471-7

Fig. 4. Neuronal seipin deficiency increases GSK3β activity and IL-6 production.

Fig. 4

a, b The bars represent the levels of PPARγ mRNA and PPARγ protein in SN of 3-M-old and 8-M-old control and seipin-nKO mice. **P < 0.01 vs. control mice (two-way ANOVA). c, d The densitometric values for GSK3β phosphorylation (p-GSK3β) at Ser9 and Tyr216 in SN of 3-M-old and 8-M-old control and seipin-nKO mice treated with rosiglitazone (rosi) for 7 days. *P < 0.05 and **P < 0.01 vs. control mice; +P < 0.05 vs. 3-M-old seipin-nKO mice; ##P < 0.01 vs. 8-M-old seipin-nKO mice (three-way ANOVA). e, f Levels of IL-6 and TNF-α in SN of 3-M-old and 8-M-old control and seipin-nKO mice treated with rosi or the GSK3β inhibitor AR-A014418 (AR) for 7 days. **P < 0.01 vs. control mice; #P < 0.05 and ##P < 0.01 vs. 8-M-old seipin-nKO mice (three-way ANOVA). g, h Levels of CHOP and GRP78 protein in SN of 3-M-old and 8-M-old control and seipin-nKO mice