. 2018 Apr 18;8:6220. doi: 10.1038/s41598-018-24437-5

Table 2.

Comparison of immune cell fractions in percent between three molecular HCC subclasses.

Immune cell type	CIBERSORT fraction in % of all infiltrating immune cells, mean ± SEM			ANOVA p-value (with Bonferroni correction)
Immune cell type	Subclass S1 (n = 19)	Subclass S2 (n = 15)	Subclass S3 (n = 34)	ANOVA p-value (with Bonferroni correction)
T cells total	45.58 ± 1.20	42.18 ± 2.21	40.47 ± 1.82
T cells CD8⁺	12.4 ± 1.70	9.82 ± 2.57	10.69 ± 1.03	0.534
T cells CD4⁺ memory resting	21.8 ± 2.02	24.2 ± 2.86	22.98 ± 1.48	0.975
T cells CD4 ⁺ memory activated	2.87 ± 0.66^a	2.31 ± 0.79	1.09 ± 0.33^a	0.03
T cells Follicular Helper	5.46 ± 1.19	5.05 ± 1.35	3.81 ± 0.66	0.321
Tregs	3.00 ± 0.79	0.81 ± 0.46	1.91 ± 0.49	0.191
B cells total	6.39 ± 0.93	5.90 ± 1.19	4.82 ± 0.49
B cells memory	2.26 ± 0.73	2.73 ± 1.68	5.22 ± 0.16	0.065
B cells naïve	4.10 ± 0.99	5.63 ± 1.22	4.31 ± 0.53	0.663
Macrophages total	28.14 ± 1.97	27.24 ± 1.41	28.81 ± 1.41
M0 macrophages	3.30 ± 0.92	2.28 ± 0.86	2.35 ± 0.55	0.326
M1 macrophages	9.32 ± 0.72^b	9.22 ± 0.81^c	12.55 ± 0.72^b,c	0.003
M2 macrophages	15.51 ± 2.04	15.75 ± 1.70	13.91 ± 1.36	0.452
M1/M2 ratio	0.98 ± 0.22	0.73 ± 0.11	1.16 ± 0.17
Mast cells	6.41 ± 1.17	9.66 ± 1.47	10.49 ± 1.06	0.115
Neutrophils	4.71 ± 0.64	4.92 ± 1.17	5.49 ± 0.62	0.753
Dendritic cells	2.17 ± 0.84	1.70 ± 0.43	2.04 ± 0.39	0.951
Monocytes	0.21 ± 0.15	0.62 ± 0.21	0.48 ± 0.17	0.485
Eosinophils	1.91 ± 0.13	0	0	0.091

^aDifferent at p = 0.037.

^bDifferent at p = 0.011.

^cDifferent at p = 0.018, ANOVA with Bonferroni correction.