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Concentration-response curves of SLIGRL-induced vasodilation in pressurized mesenteric arteries from WT (A) and db/db (B) mice. SLIGRL stimulated endothelium-dependent vasodilation which was insensitive to blockade of NO synthase with L-NAME (L-N). IKCa and SKCa were selectively blocked with TRAM-34 (TR) and apamin (Ap), respectively, which attenuated the response. Increasing extracellular K+ concentration to 45 mM (K+) completely abolished any dilatory response. n = 7–9.
