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. 2018 Apr;103-105:36–46. doi: 10.1016/j.vph.2017.12.063

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Forskolin plus U46619 do not augment contractions to acetylcholine and histamine in porcine coronary arteries. Cumulative concentration-response curves to acetylcholine (ACh) (a) and histamine (b), under control conditions and the effect of forskolin (0.1 μM) plus U46619. There was no significant difference in the R_max values for either compound, or in the logEC₅₀ values for ACh, but there was a small but significant difference in logEC₅₀ values for histamine, indicating a slightly reduced potency in the presence of forskolin plus U46619 (P < 0.01, extra sum of squares F-test). Data are mean ± S.E.M.