Fig. 6.
Contractile responses to UDP-glucose and MRS2690 are unaffected by the selective P2Y6 receptor antagonist MRS2578. Effect of MRS2578, on concentration-response curves to (a) UDP-glucose and (b) MRS2690 in porcine coronary arteries. UDP-glucose and MRS260 caused concentration-dependent contractions in the presence of forskolin and U46619. Contractions to UDP-glucose were unaffected by MRS2578 or by prior incubation of the UDP-glucose solution and tissues with apyrase (5 U/ml, > 30 min) (a). Contractions to MRS2690 were also unaffected by MRS2578. Data are mean ± S.E.M.