Results from Cross-Sectional Model. Values for baseline apathy (scores on the NPI-Q apathy item) as predicted by the reduced cross-sectional general linear model including posterior cingulate FDG metabolism (F=4.46; df=1,396; p=0.035), diagnosis (F=14.89; df=2,396; p<0.0001), sex (F=5.04; df=1,396; p=0.025), and baseline antidepressant medications (presence or absence; F=4.55; df=1,396; p=0.034). Symbols designate values. Variation in the symbols and lines connecting them differentiate various groupings. To indicate diagnosis: circles = AD dementia; squares = MCI; triangles = CN; for sex: dashed line = male; solid line = female; for antidepressant medication use: large symbol = presence of antidepressant medication; small symbol = absence of antidepressant medication. NPI-Q: Neuropsychiatric Inventory Questionnaire; FDG: 18F-fluorodeoxyglucose; AD: Alzheimer’s disease; MCI: mild cognitive impairment; CN: cognitively normal.