Table 1.
Comparison of RNA Integrity Number Values of Control Cases Versus Disorders That Had at Least 12 Cases
| Case | n | PMI (hours) | RIN (cortex) | RIN (cerebellum) | pH |
|---|---|---|---|---|---|
| ALD | 35 | 14 ± 9.1 | 7.3 ± 1.1 | 6.9 ± 1.4 | 5.8 ± 0.3 |
| Alzheimer's disease | 74 | 12.8 ± 8.7a | 6.2 ± 1.2a | 6.5 ± 1.2a | 5.8 ± 0.6 |
| ALS | 34 | 17.1 ± 9.7 | 6.7 ± 0.9 | 6.9 ± 1.3 | 5.8 ± 0.5 |
| Autism | 60 | 21.7 ± 10.5 | 6.7 ± 1.1b | 7.1 ± 1.3 | 6.3 ± 0.5a |
| Depression | 22 | 18.9 ± 7.4 | 7.3 ± 0.9 | 7.4 ± 1 | 6.1 ± 0.5 |
| Dystonia | 20 | 20 ± 11.8 | 6.4 ± 1.5 | 6.8 ± 1.1 | 6 ± 0.5 |
| Epilepsy | 28 | 23.3 ± 8.8 | 7 ± 0.8 | 7.6 ± 0.7 | 5.6 ± 0.5 |
| Parkinson's disease | 16 | 19.2 ± 7.8 | 6.3 ± 1.4 | 6.6 ± 1.4 | 5.9 ± 0.7 |
| Prader–Willi syndrome | 12 | 19.8 ± 8 | 7.1 ± 0.9 | 7.1 ± 1.1 | 6 ± 0.5 |
| Controls | 506 | 18.7 ± 8.9 | 7.2 ± 1.2a | 7.5 ± 1.2a | 5.8 ± 0.5a |
| All conditions, other than controls | 562 | 18.4 ± 11.4 | 6.7 ± 1.3a | 6.8 ± 1.5a | 5.9 ± 0.6a |
Alzheimer's disease (PMI): af = 6, df = 9, p < 0.001, Bonferroni p < 0.001; Alzheimer's disease (RIN cortex): af = 8.5, df = 9, p < 0.001, Bonferroni p < 0.001; Alzheimer's disease (RIN cerebellum): af = 7.9, df = 9, p < 0.001, Bonferroni p < 0.001; autism (RIN cortex): bf = 8.5, df = 9, p < 0.001, Bonferroni p = 0.03; autism (pH): af = 4.5, df = 9, p < 0.001, Bonferroni p < 0.001; all conditions, other than controls (RIN cortex), at = 7.4, df = 1065, Bonferroni p < 0.001; all conditions, other than controls (RIN cerebellum): at = 9.7, df = 1057, Bonferroni p < 0.001; all conditions, other than controls (pH): at = 3.3, df = 763, Bonferroni p < 0.001.
ALD, adrenoleukodystrophy, X-linked; ALS, amyotrophic lateral sclerosis; PMI, postmortem interval; RIN, RNA integrity number.