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. 2018 May;1864(5Part A):1609–1621. doi: 10.1016/j.bbadis.2018.01.028

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — - Vps33b and Vipar deficient murine skin does not show gross changes in the morphology of dermal collagen fibres but areas of thin basement membrane suggest subtle defects in collagen structure. A - Picrosirius red staining of control (Vps33b^+/+ and Vipas39^+/+), Vps33b^fl/flER^T2 and Vipas39^fl/flER^T2 skin. In picrosirius red images collagen stains red. Images are representative of results from three independent murine biopsies per genotype. B - TEM images of collagen fibrils in control, Vps33b^fl/flER^T2 and Vipas39^fl/flER^T2 dermis. All images are 0.8 μm². Images are representative of at least two independent murine biopsies per genotype. C - TEM images of the dermo-epidermal junction in control, Vps33b^fl/flER^T2 and Vipas39^fl/flER^T2 skin. Areas of thinner basement membrane (arrow). All images are 1 μm². SB and dermis (D) are indicated. Images are representative of at least two independent murine biopsies per genotype.