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. 2018 Apr 18;38(16):3901–3910. doi: 10.1523/JNEUROSCI.1788-17.2018

Figure 2.

Figure 2.

Kainate receptor activation mobilizes eCBs in dSPNs. A, Time course of KA effect on corticostriatal synapses in dSPN in the presence of the CB1 receptor antagonist AM251 (2 μm). B, Representative traces from one experiment of corticostriatal EPSCs recorded in a dSPN in the presence of AM251 before and after KA application. Calibration: 50 pA, 40 ms. C, PPR measurements of dSPN corticostriatal EPSCs at interstimulus intervals of 40 ms before and after KA in the presence of AM251. D, Average KA depression in dSPNs and iSPNs. KA-mediated effect is selective for dSPNs. E, AM251 prevents the KA-mediated depression of mEPSC frequency in dSPNs. F, Representative mEPSC traces in AM251 before and after 100 nm KA application. Calibration: 10 pA,100 ms.