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. 2018 Apr 11;12(Suppl 1):10. doi: 10.1186/s12918-018-0529-2

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Overall time-course simulation showing cytosolic (CAC) and mitochondrial (CAM) Ca ²⁺ ion concentration along with tendency for opening of PTP in high-conductance state (PTPh) over a time of 500ms in the absence of β-amyloid deposition (by setting V₁ = 0, V_α = 0 and K₁ = 0)