Table 13.

List of model equations used in calculation of mitochondrial Fo/F1-ATPase equations (obtained from [11])

Equation	Biological significance
AF1=(1.71e9)∗(ATPm)/(ADPmf∗pim)	AF1 = affinity bracketed expression
$V_{F1}^D=\mathit{\text{exp}}(0.112\ast \mathit{\text{PSI}})$	ATPase potential generated
F0/F1 ATPase phosphorylation of ADPm
f1=10.5∗AF1	Variable f1
$f_2=166\ast V_{F1}^D$	Variable f2
$f_3=(4.85e-12)\ast A_{F1}\ast V_{F1}^D$	Variable f3
f4=(1e7+0.135∗AF1)∗275	Variable f4
$f_5=(7.74+(6.65e-8)\ast A_{F1})\ast V_{F1}^D$	Variable f5
Jp,F1=−60∗ρF1∗((f1−f2+f3)/(f4+f5))	Rate of F0/F1 ATPase phosphorylation
$J_{H,F1}=-180\ast {\rho }_{F1}\ast \left(0.213+f_1-169\ast V_{F1}^D\right)/\left(f_4+f_5\right)$	Proton flux due to ATPase
JH,leak=ρleak∗(PSI+24.6)	Mitochondrial membrane proton leak
fPDH=1/(1+(1.1∗(1+(15/(1+(CAM/0.05))2))))	Fraction of activated pyruvate
Jred=Jred,basal+6.3944∗fPDH∗Jgly,total	NADH reduction rate
ATP/ADP antiport flux
ant1=([ATP4−]i/[ADP3−]i)∗([ADP3−]m/[ATP4−]m)∗exp(−PSI/26.7)	Variable ant1
ant2=1+([ATP4−]i/[ADP3−]i)∗exp(−PSI/53.4)	Variable ant2
ant3=1+([ADP3−]m/[ATP4−]m)	Variable ant3
JANT=Jmax,ANT∗((1−ant1)/(ant2∗ant3))	Rate of Adenine Nucleotide Translocator (ANT) activity
Phosphorylation of ADPm from TCA cycle
Jp,TCA=(Jred,basal/3)+0.84∗fPDH∗Jgly,total	Unbound, 3- charged mitochondrial ADP concentration