Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr 18;18:439. doi: 10.1186/s12885-018-4364-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 2 — miRNA relative expression detected by qRT-PCR in salivary EV samples from OSCC patients compared to normal subjects. (a) Expression levels of miRNAs that were significantly up-regulated in patients. (b) Expression levels of miRNAs that were exclusively expressed by OSCC patients. The bars represent mean relative expression (2^-∆∆Ct) of control and patient groups ± SEM, p value (two-sided Mann-Whitney test) are reported. ROC curve describing predictive potency of the up-regulated miRNAs as a diagnostic test. The curves represent specificity versus sensitivity of miR-512-3p (c), miR-412-3p (d). Data are derived from miRNAs’ expression levels (RQ) of OSCC patients and controls. The big gray dots indicate the optimal threshold value of sensitivity and specificity determined by the maximum Youden’s index (sensitivity+specificity-1)