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. Author manuscript; available in PMC: 2018 Apr 19.
Published in final edited form as: Science. 2017 Nov 9;358(6367):1182–1187. doi: 10.1126/science.aap9674

Fig. 3. Scope of program-scale deuteration.

Fig. 3

Reaction conditions: photoredox catalyst 1 or 12 (2 mol %), triisopropylsilanethiol 13 (30 mol %), D2O (50 equivalents), Li2CO3 (1.2 equivalents, added when substrate is used as its acid salt), NMP, rt, 34-W blue LED or integrated photoreactor. The products were isolated as the appropriate acid salts shown in parentheses. Ac, acetyl group. *The two protons at the α-amino methylene position are diastereotopic and are labeled to different extents.