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. Author manuscript; available in PMC: 2018 Apr 19.
Published in final edited form as: Biochemistry. 2017 Nov 10;56(47):6200–6210. doi: 10.1021/acs.biochem.7b00741

Figure 3. B-ZIP TF binding to DNA 8-mers containing cytosine or 5mC.

Figure 3

(A) 8-mer Z-scores for Zta binding to DNA 8-mers with cytosine (x-axis) or 5mC in one DNA strand (y-axis). Of the 65,536 8-mers on the array, 6,561 8-mers do not contain a cytosine, acting as an internal control (grey spots). The remaining 58,975 8-mers are divided into three groups: green spots are 8-mers containing the C/EBP half site GCAA, red and blue spots are 8-mers with TRE half sites CTCA and GTCA, and black spots are all other 8-mers that contain cytosine. A selection of well-bound 8-mers are highlighted and their sequences are provided. Sequence logos generated using the top 50 Zta bound 8-mers containing 5mC are shown. (B) Same as in (A) but for cJun|cFos heterodimers. (C) Same as in (A) but for CREB1 homodimers (data from 15) (D) same as in (A) but for CEBPB.