Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Cancer Res. 2018 Jan 16;78(7):1739–1750. doi: 10.1158/0008-5472.CAN-17-1671

Figure 3. Histopathology of p53 signature.

Figure 3

We were able to identify a p53 signature in a discrete row of cells which are morphologically indiscernible from the surrounding cells as is evident from the H&E (A) and p53 staining (B). The proliferative fraction (Ki67) (C) was consistently lower. The pSTAT3 Tyr705 expression was still moderate (D) coupled with low PIAS3 expression (E). Histopathology of tubal intraepithelial lesions in transition (TILT). The H&E for TILT displays moderate nuclear atypia, intermediate N/C ratio, and distinct nucleoli, Tubal epithelia showed nuclear enlargement and molding, some stratification, mild nuclear enlargement, polarity loss, and prominent nucleoli (F). A short stretch of strong p53 expression (G) and <25% of Ki67 expression (Ki67 low) (H) was observed. Further there was an abundance of pSTAT3 Tyr705 expression (I) and relatively low but noticeable PIAS3 expression (J). All areas of interest are marked by a yellow arrow.