Table 2.

Hydrogen bonds between HA and bound receptor analogues

Ligand	DH1 HA – 6’SLN		DH1D HA – 6’SLN		DH1E HA -6’SLN		DH1E HA-3’SLN
	Interaction pairs	Distance (Å)	Interaction pairs	Distance (Å)	Interaction pairs	Distance (Å)	Interaction pairs	Distance (Å)
Sia-1	O1A······T136 OG1	2.58	O1A······T136 OG1	2.63	O1A······T136 OG1	2.68	O1A······T136 OG1	2.75
	O1A······Q22 6 NE2	3.00
	O1B······A137 N	2.66	O1B······A13 7 N	2.62	O1B······A13 7 N	2.82	O1B······A13 7 N	2.88
	O4······V135 O	3.51	O4······V135 O	3.69	O4······V135 O	3.63	O4······V135 O	3.58
	N5······V135 O	2.99	N5······V135 O	2.83	N5······V135 O	2.92	N5······V135 O	2.82
	O8······Y98 OH	2.76	O8······Y98 OH	2.68	O8······Y98 OH	2.71	O8······Y98 OH	3.06
	O9······Y98 OH	2.97	O9······Y98 OH	2.61	O9······Y98 OH	2.86	O9······Y98 OH	3.24
	O9······H183 NE2	3.14	O9······H183 NE2	2.85	O9······H183 NE2	3.05	O9······H183 NE2	3.11
					O9······E190 OE1	2.48	O9······E190 OE1	2.38
			O9······S228 OG	3.11	O9······S228 OG	2.85	O9······S228 OG	3.12
Gal-2	O3······K222 NZ	3.00	O3······K222 NZ	2.79	O3······K222 NZ	3.16
	O3······D225 OD2	2.81	O3······D225 OD2	3.65
	O3······D225 O	3.28	O3······D225 O	3.70	O3······G225 O	3.07
	O4······D225 O	2.56	O4······D225 O	2.75	O4······G225 O	3.34
GalNAc-3	N2······D190 OD1	2.97

Hydrogen atoms were calculated by LigPlot+.