Table 2.
Baseline and echocardiography data of the included studies.
| Year of publication | Stortecky et al. [18] | Wilbring et al. [19] | Papadopoulos et al. [20] | Nguyen et al. [21] | Greason et al. [22] | Wendt et al. [23] | Conte et al. [24] | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2011 | 2013 | 2014 | 2014 | 2014 | 2015 | 2015 | ||||||||
| Number of patients | 80 | 106 | 80 | 255 | 288 | 113 | 226 | |||||||
| TAVR | SAVR | TAVR | SAVR | TAVR | SAVR | TAVR | SAVR | TAVR | SAVR | TAVR | SAVR | TAVR | SAVR | |
| Patients who underwent TAVR/SAVR | 40 | 40 | 53 | 53 | 40 | 40 | 107 | 148 | 148 | 140 | 62 | 51 | 115 | 111 |
| Age (mean ± SD) | 78.2 ± 6 | 70.6 ± 8 | 78.1 ± 5.5 | 77.6 ± 2.7 | 81 ± 4 | 80 ± 3 | 79.8 ± 7.9 | 72.5 ± 8.8 | 80.7 ± 7 | 82.3 ± 6.2 | 78.7 ± 5.9 | 71.1 ± 10.8 | 82 ± 5.8 | 81 ± 5.9 |
| Body mass index (mean ± SD) | 27.4 ± 5 | 28 ± 5 | 27.9 ± 4.0 | 27.3 ± 4.2 | N/A | N/A | 27.2 ± 5 | 28.4 ± 5.3 | N/A | N/A | 27.1 ± 4.1 | 26.6 ± 3.7 | N/A | N/A |
| Male (%) | 32 (80) | 33 (83) | 26 (65) | 35 (66) | 29 (73) | 29 (73) | 81 (75.7) | 116 (78.4) | 120 (81) | 111 (79) | 43 (69.4) | 38 (74.5) | 91 (79.1) | 87 (78.4) |
| Diabetes mellitus (%) | 19 (48) | 13 (33) | 28 (52.8) | 23 (43.4) | 17 (42) | 14 (35) | 48 (44.9) | 71 (48) | 74 (50) | 70 (50) | 24 (38.7) | 22 (43.1) | 49 (42.6) | 58 (52.3) |
| Systemic hypertension (%) | 34 (85) | 36 (90) | N/A | N/A | 16 (40) | 18 (45) | 105 (98.1) | 138 (93.2) | N/A | N/A | 57 (91.9) | 45 (88.2) | N/A | N/A |
| NYHA III/IV (%) | 26 (65) | 26 (65) | N/A | N/A | N/A | N/A | N/A | N/A | 140 (94.6) | 131 (93.6) | N/A | N/A | 96 (83.5) | 98 (88.3) |
| Coronary artery disease (%) | 40 (100) | 40 (100) | 53 (100) | 53 (100) | 33 (83) | 30 (75) | 86 (80.4) | 126 (85.1) | 148 (100) | 140 (100) | N/A | N/A | 115 (100) | 111 (100) |
| Myocardial infarction (%) | 20 (50) | 14 (35) | N/A | N/A | N/A | N/A | N/A | N/A | 60 (41) | 62 (45) | N/A | N/A | N/A | N/A |
| PCI (%) | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | 59 (40.4) | 50 (35.7) | N/A | N/A | 49 (42.6) | 50 (45) |
| Renal failure/dialysis (%) | N/A | N/A | 35 (66) | 32 (60.4) | 20 (50) | 16 (40) | N/A | N/A | N/A | N/A | 12 (23.5) | 13 (21) | 10 (8.7) | 8 (7.3) |
| Cerebrovascular disease (%) | 4 (10) | 6 (15) | 10 (18.9) | 8 (15.1) | 9 (23) | 8 (20) | 41 (38.3) | 45 (30.4) | 49 (35.5) | 40 (29.4) | N/A | N/A | 37 (32.7) | 32 (28.8) |
| Peripheral vascular disease (%) | 21 (53) | 9 (23) | N/A | N/A | 13 (33) | 11 (27) | 48 (44.9) | 42 (28.4) | 75 (50.7) | 67 (48.6) | 32 (52) | 15 (29.4) | 47 (41.6) | 57 (51.8) |
| COPD (%) | 7 (17.5) | 7 (17.5) | 5 (9.4) | 4 (7.5) | 9 (23) | 8 (20) | 55 (51.4) | 44 (29.7) | 67 (45.3) | 58 (41.4) | 16 (25) | 17 (33.3) | 48 (41.7) | 43 (38.7) |
| STS score (median or mean ± SD) | 7.6 ± 7 | 6.3 ± 6 | N/A | N/A | 24 ± 6 | 19 ± 6 | 11.8 | 7.1 | 11.8 ± 3.3 | 12 ± 3.1 | 12 ± 10 | 7.1 ± 5.2 | 7.3 ± 2.7 | 8.0 ± 3.5 |
| EuroSCORE (mean ± SD) | 33.5 ± 17 | 20.2 ± 14 | 29.9 ± 14 | 26.4 ± 12.9 | 11.1 ± 2.8 | 10.4 ± 3 | N/A | N/A | 34.6 ± 16.8 | 33.8 ± 15.3 | 36.4 ± 17.4 | 22.2 ± 17.5 | 25.6 ± 16.2 | 24.2 ± 15.8 |
| Previous CABG (%) | 40 (100) | 40 (100) | 48 (90.6) | 49 (92.4) | N/A | N/A | 107 (100) | 148 (100) | 148 (100) | 140 (100) | 59 (95.2) | 36 (70.6) | 115 (100) | 111 (100) |
| Previous AVR (%) | 0 | 0 | 5 (9.4) | 4 (7.6) | N/A | N/A | 0 | 0 | 0 | 0 | 2 (3.2) | 10 (19.6) | 0 | 0 |
| Other cardiac surgery (%) | 0 | 0 | 0 | 0 | N/A | N/A | 0 | 0 | 0 | 0 | 1 (1.6) | 5 (9.8) | 0 | 0 |
| Mean AVA (cm2) (mean ± SD) | N/A | N/A | N/A | N/A | 0.63 ± 0.29 | 0.68 ± 0.31 | 0.7 ± 0.12 | 0.76 ± 0.23 | 0.68 ± 0.2 | 0.66 ± 0.2 | N/A | N/A | N/A | N/A |
| MAVPG (mmHg) (mean ± SD) | 39 ± 15 | 48.6 ± 16 | 44 ± 4 | 55 ± 10 | 57 ± 21 | 51 ± 16 | 43.3 ± 13.0 | 42.0 ± 12.6 | 65.9 ± 20.3 | 68.9 ± 22.2 | N/A | N/A | N/A | N/A |
| LVEF % (mean ± SD) | 46.5 ± 15 | 49.8 ± 14 | N/A | N/A | 48 ± 14 | 47 ± 12 | 43.3 ± 13.1 | 46.9 ± 14.8 | 50.4 ± 13.3 | 52.2 ± 11.5 | 48.1 ± 13 | 49.9 ± 12.3 | N/A | N/A |
TAVR/SAVR, transcatheter/surgical aortic valve replacement; NYHA, New York Heart Association; PCI, percutaneous coronary intervention; COPD, chronic obstructive pulmonary disease; CABG, coronary artery bypass grafting; AVA, aortic valve area; MAVPG, mean aortic valve pressure gradient.