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. 2018 Apr 12;9:207. doi: 10.3389/fphys.2018.00207

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Copyright © 2018 Perissinotti, De Biase, Guo, Yang, Lee, Clancy, Duff and Noskov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative current traces of hERG1a and hERG1b channels and their current-voltage relationship at room temperature. (A) Selected current traces recorded from HEK cells and elicited by the voltage protocol shown in the top. (B) Normalized tail currents against voltage. The solid lines correspond to the fitted Boltzmann functions and symbols correspond to data. All data are listed as mean ± SEM. hERG1a (n = 10), hERG1b (n = 10). (C) Currents measured at the end of each step were used to construct the current-voltage (I-V) relationship. All data are shown as mean ± SEM. hERG1a (n = 10), hERG1b (n = 10).