Table 3.

M-model 2 rate constants for transitions within hERG gating for a-isoform and b-isoform.

Transition	Parameter name		Rates		ratio b/a
			b-Isoform	a-Isoform
C3 → C2	ae	α	1.19 E-2	3.77 E-3	3.17
		β	2.17 E-2	3.29 E-2	0.66
C2 → C3	be	α	1.82 E-2	2.44 E-2	0.74
		β	−3.79 E-2	−6.77 E-2	0.56
C2 → C1	ain	α	9.29 E-2	3.59 E-2	2.59
C1 → C2	bin	α	1.09 E-1	1.65 E-2	6.62
I → O	ai	α	5.11 E-2	1.74 E-2	2.93
		β	2.09 E-2	2.87 E-2	0.73
O → I	bi	α	1.79 E-2	9.26469 E-3	1.94
		β	−2.15 E-2	−2.347 E-2	0.92
C1 → O	aa	α	1.55 E-1	8.80 E-2	1.76
		β	9.60 E-3	1.02 E-2	0.94
O → C1	bb	α	7.82 E-2	5.11 E-3	15.28
		β	−3.54 E-2	−4.44 E-2	0.80
C1 → I	bi*	α	9.32E-07	1.02E-09	910.41
		β	1.621E-05	7.99E-06	2.03

α (1/ms) indicates voltage independent rate, and β (1/mV) indicates voltage dependent rate as follows: k = α^*exp(β^*V).

^*Constraint by microscopic reversibility. Bold values indicate moderate change of the corresponding transitions calculated as a ratio. Transitions that are strongly affected are shown in bold red. Transitions that are affected the most are shown as underlined red bold values. For additional details on the optimizations and original model parameters see Tables S1–S4.