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. 2018 Mar 23;7(6):e006207. doi: 10.1161/JAHA.117.006207

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© 2018 The Authors and Recombinetics. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Immunohistochemical analysis of plaques in the right coronary artery. A, Immunohistochemistry staining for CD107a, α‐smooth muscle actin (α‐SMA), CD31, and E06 highlights inflammation, neointimal hyperplasia, endothelial cells, and oxidized phospholipids, respectively, predominantly in gain‐of‐function (GOF) groups. B, CD107a, α‐SMA, and E06 immunostaining areas were quantified on HALO platform (Indica Labs, Corrales, NM), and results were presented as total CD107a‐ or α‐SMA–positive area per plaque area and the percentage of plaque area. Mean and SD are displayed. *P<0.05 compared with control; ^† P<0.05 compared with proprotein convertase subtilisin‐like/kexin type 9 (PCSK9) GOF receiving standard diet using 1‐way ANOVA, multiple comparison analysis. ATH indicates atherogenic.