Table 3.

Collagen Type I Turnover Biomarkers in Controls and FD Subgroups

	Controls (n=20)	FD Subgroups			P Valuea	P Valueb
		1 (n=20)	2 (n=20)	3 (n=20)
PICP, ng/mL	107.3 (39.3)	148.5 (129.0)	115.7 (88.8)	219.0 (98.4)	0.006	0.001
PICP/B‐AP	10.1 (4.3)	16.2 (10.3)	12.7 (9.1)	19.4 (24.1)	0.003	0.001
ICTP, ng/mL	0.34 (0.20)	0.25 (0.27)	0.20 (0.19)	0.29 (0.23)	0.687	0.236
ICTP/TRAP5b	0.11 (0.07)	0.16 (0.10)	0.11 (0.07)	0.13 (0.06)	0.011	0.186
MMP1, ng/mL	16.8 (26.3)	13.5 (19.3)	14.1 (4.3)	9.6 (4.6)	0.159	0.002
MMP2, ng/mL	440.3 (541.0)	341.8 (849.5)	356.5 (187.0)	318.7 (101.9)	0.872	0.108

Data are shown as median (interquartile range). B‐AP indicates bone‐specific alkaline phosphatase; FD, Fabry disease; ICTP, carboxyterminal telopeptide of type I collagen; MMP, matrix metalloproteinase; PICP, carboxyterminal propeptide of procollagen type I; TRAP5b, tartrate‐resistant acid phosphatase type 5b.

^aControls vs FD disease subgroup 1.

^bBetween FD subgroups.