Table 4.

Correlation Between Type I Collagen Turnover Biomarkers and Cardiac Imaging Parameters

	PICP (ng/mL)	PICP/B‐AP	ICTP (ng/mL)	ICTP/TRAP5b	MMP1 (ng/mL)	MMP2 (ng/mL)
Echocardiogram
dIVS, mm	0.438a	0.378a	0.178	−0.017	−0.519a	−0.300a
dLVPW, mm	0.322a	0.234	0.204	0.043	−0.438a	−0.294a
LVMi, g/m2.7	0.378a	0.313a	0.197	0.013	−0.484a	−0.235
LA area, cm2	0.173	0.066	0.092	0.080	−0.129	−0.239
DT, ms	0.103	0.059	−0.024	−0.187	−0.294a	−0.145
S′(s), cm/s	−0.023	0.071	0.020	−0.046	0.354a	0.188
S′(l), cm/s	−0.029	−0.017	−0.063	0.083	0.230	0.127
E′(s), cm/s	−0.125	−0.113	0.130	0.139	0.354a	0.288
E′(l), cm/s	−0.037	0.000	0.127	0.234	0.280a	0.200
E/E′(a)	0.105	0.005	0.027	−0.082	−0.097	0.087
Cardiac MRI
LGE (yes)	88.8a	12.5a	0.066	−0.024	−5.27	−239.3

Data are shown as mean difference for categorical variables and as ρ for continuous variables. B‐AP indicates bone‐specific alkaline phosphatase; dIVS, diastolic interventricular septal thickness; dLVPW, diastolic left ventricular posterior wall thickness; DT, E‐wave decelerating time; E/E′(a), left ventricular rapid filling velocity/average (septal and lateral) early diastolic myocardial velocity measured at the mitral annulus; E′(l), early diastolic myocardial velocity measured at the lateral corner of the mitral annulus; E′(s), early diastolic myocardial velocity measured at the septal corner of the mitral annulus; ICTP, carboxyterminal telopeptide of type I collagen; LA, left atrium; LGE, late gadolinium enhancement; LVMi, left ventricular mass indexed for height; MMP, matrix metalloproteinase; MRI, magnetic resonance imaging; PICP, carboxyterminal propeptide of procollagen type I; S′(l), systolic myocardial velocity measured at the lateral corner of the mitral annulus; S′(s), systolic myocardial velocity measured at the septal corner of the mitral annulus; TRAP5b, tartrate‐resistant acid phosphatase type 5b.

^a P<0.05.