Table 6.
Predictive Model of LV Mass by Univariate and Multivariable Regression Analysis
| LV Mass (Univariate) | LV Mass (Multivariable) | |||
|---|---|---|---|---|
| R | P Value | β | P Value | |
| PICP | 0.413 | 0.001 | 0.081 | 0.418 |
| PICP/B‐AP | 0.510 | <0.001 | 0.919 | <0.001 |
| ICTP | 0.170 | 0.202 | ||
| ICTP/TRAP5b | 0.016 | 0.906 | ||
| MMP1 | −0.339 | 0.010 | −0.066 | 0.646 |
| MMP2 | −0.285 | 0.032 | 0.016 | 0.910 |
| PICP/ICTP | 0.217 | 0.102 | ||
| PICP/ICTP adjusted | 0.379 | 0.004 | 0.035 | 0.751 |
| Age | 0.486 | <0.001 | 0.392 | 0.010 |
| Age at diagnosis | 0.274 | 0.035 | 0.066 | 0.644 |
| Age at ERT initiation | 0.310 | 0.058 | ||
| Time in ERT | 0.320 | 0.050 | −0.094 | 0.288 |
| Plasma α‐gal A (female) | −0.027 | 0.906 | ||
| Plasma α‐gal A (male) | −0.004 | 0.987 | ||
| MSSI | 0.631 | <0.001 | 0.041 | 0.686 |
| FIPI | 0.658 | <0.001 | −0.149 | 0.417 |
| Plasma lyso‐Gb3 | 0.409 | 0.009 | −0.012 | 0.898 |
| NT‐proBNP | 0.414 | 0.040 | 0.028 | 0.759 |
| eGFR | −0.388 | 0.003 | −0.057 | 0.645 |
α‐gal A indicates α‐galactosidase A; B‐AP, bone‐specific alkaline phosphatase; eGFR, estimated glomerular filtration rate; FIPI, Fabry International Prognostic Index; ICTP, carboxyterminal telopeptide of type I collagen; lyso‐Gb3, globotriaosylsphingosine; LV, left ventricular; MMP, matrix metalloproteinase; MSSI, Mainz Severity Score Index; NT‐proBNP, N‐terminal probrain natriuretic peptide; PICP, carboxyterminal propeptide of procollagen type I; TRAP5b, tartrate‐resistant acid phosphatase type 5b.