Table 6.
Association of AF With Incident Dementia, ARIC Study, 1990 to 2013
| Variable | No AF (n=10 504) | AF (n=2011) | P Value |
|---|---|---|---|
| No. of dementia events | 977 | 180 | … |
| Person‐years | 218 165 | 8485 | … |
| Incidence rate (95% CI)a | 4.48 (4.20–4.77) | 21.21 (18.28–24.49) | … |
| HR (95% CI) | |||
| Model 1 | 1 (Reference) | 1.37 (1.16–1.61) | <0.001 |
| Model 2 | 1 (Reference) | 1.31 (1.11–1.55) | 0.001 |
| Model 3 | 1 (Reference) | 1.23 (1.04–1.45) | 0.02 |
Model 1 is adjusted for age, sex, and race‐field center. Model 2 is additionally adjusted for education, occupation, apolipoprotein E, smoking, body mass index, systolic blood pressure, diastolic blood pressure, use of hypertensive medication, diabetes mellitus, prevalent coronary heart disease, and prevalent heart failure. Model 3 is model 2 and additionally adjusted for prevalent and incident stroke. AF indicates atrial fibrillation; ARIC, Atherosclerosis Risk in Communities; CI, confidence interval; and HR, hazard ratio.
a
Incidence rate is per 1000 person‐years.