Table 4.
PEAR‐2 Association Tested for Replication in PEAR for Blacks
| SNP | CHR | BP | Nearest Gene | Minor Allele | MAF | PEAR‐2 Chlorthalidone Response | PEAR Hydrochlorothiazide Response | Meta‐Analysis | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| β | P Value | β | One‐Sided P Value | β | P Value | ||||||
| rs9943291 | 1 | 120 292 290 | HMGCS2 | G | 0.0637 | 12.51 | 4.17×10−08 | 5.54 | 0.023 | 10.01 | 3.71×10−08 |
| rs61824877 | 1 | 200 242 632 | 69 kb 3′ of C1orf98 | A | 0.0606 | 12.74 | 4.82×10−09 | 3.87 | 0.135 | 9.08 | 5.20×10−08 |
BP indicates base‐pair position: hg19 position; CHR, chromosome; D, deletion; MAF, minor allele frequency; PEAR, Pharmacogenomic Evaluation of Antihypertensive Response; SE, standard error of the beta coefficient; SNP, single‐nucleotide polymorphism; β, regression coefficient for minor allele.