Table 8.
Multivariate Analysis for Predictors of All‐Cause Mortality During Follow‐up
| Total | HFrEF | HFpEF | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | HR | 95% CI | P Value | |
| 3‐month mortality | |||||||||
| WRF | 1.66 | 1.22 to 2.25 | 0.001 | 1.59 | 1.10 to 2.29 | 0.013 | 1.86 | 1.06 to 3.27 | 0.031 |
| Age >70 y | 2.46 | 1.81 to 3.35 | <0.001 | 2.50 | 1.77 to 3.55 | <0.001 | 2.36 | 1.22 to 4.60 | 0.011 |
| Female sex | 1.37 | 1.04 to 1.80 | 0.028 | NA | NA | ||||
| BMI <25 kg/m2 | 1.69 | 1.21 to 2.36 | 0.002 | 1.73 | 1.14 to 2.63 | 0.010 | NA | ||
| Hb <12 g/dL | 1.30 | 0.99 to 1.70 | 0.062 | 1.41 | 1.02 to 1.95 | 0.038 | NA | ||
| Na <135 mmol/L | 1.67 | 1.28 to 2.18 | <0.001 | 1.87 | 1.37 to 2.54 | <0.001 | NA | ||
| UA >7 mg/dL | 1.34 | 1.04 to 1.74 | 0.024 | NA | 1.86 | 1.14 to 3.03 | 0.013 | ||
| CRP >0.5 mg/dL | 1.46 | 1.13 to 1.89 | 0.004 | 1.43 | 1.06 to 1.94 | 0.020 | 1.63 | 1.00 to 2.64 | 0.049 |
| High BNP or NTproBNP | 1.76 | 1.32 to 2.36 | <0.001 | 1.95 | 1.35 to 2.84 | <0.001 | NA | ||
| 12‐month mortality | |||||||||
| WRF | 1.39 | 1.14 to 1.69 | 0.001 | 1.35 | 1.06 to 1.71 | 0.014 | 1.54 | 1.08 to 2.18 | 0.016 |
| Age >70 y | 2.20 | 1.80 to 2.69 | <0.001 | 2.30 | 1.83 to 2.90 | <0.001 | 1.95 | 1.28 to 2.98 | 0.002 |
| Female sex | 1.29 | 1.07 to 1.55 | 0.007 | NA | NA | ||||
| BMI <25 kg/m2 | 1.47 | 1.20 to 1.82 | <0.001 | 1.31 | 1.02 to 1.68 | 0.038 | 1.94 | 1.33 to 2.84 | 0.001 |
| Diabetes mellitus | 1.18 | 1.00 to 1.41 | 0.053 | 1.28 | 1.04 to 1.58 | 0.022 | NA | ||
| CRF | 1.36 | 1.10 to 1.69 | 0.005 | 1.43 | 1.11 to 1.84 | 0.006 | NA | ||
| Hb <12 g/dL | 1.43 | 1.19 to 1.73 | <0.001 | 1.46 | 1.17 to 1.83 | 0.001 | NA | ||
| Na <135 mmol/L | 1.64 | 1.37 to 1.96 | <0.001 | 1.73 | 1.39 to 2.14 | <0.001 | 1.42 | 1.01 to 2.00 | 0.047 |
| UA >7 mg/dL | 1.20 | 1.01 to 1.43 | 0.036 | NA | 1.57 | 1.15 to 2.16 | 0.005 | ||
| CRP >0.5 mg/dL | 1.32 | 1.11 to 1.56 | 0.002 | 1.34 | 1.09 to 1.65 | 0.005 | NA | ||
| High BNP or NTproBNP | 1.49 | 1.23 to 1.79 | <0.001 | 1.68 | 1.33 to 2.14 | <0.001 | NA | ||
BNP indicates brain natriuretic peptide; CI, confidence interval; CRF, chronic renal failure; CRP, C‐reactive protein; Hb, hemoglobin; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; HR, hazard ratio; Na, sodium; NA, not applicable; NTproBNP, N‐terminal pro‐brain‐type natriuretic peptide; OR, odds ratio; UA, uric acid; WRF, worsening renal function.