Figure 1.

LPS reduces hepatic CETP expression, paralleled by decreased expression of resting Kupffer cell markers and increased expression of macrophage activation markers. Female APOE*3‐Leiden.CETP mice fed a Western‐type diet were intraperitoneally injected with 25 μg LPS, after which mice were euthanized at the indicated time points. Livers were assayed for mRNA of (A) Tnfa, Il‐1β, Mcp‐1; (B) CETP and (C) Clec4f, Vsig4, Ly6C. The correlations between hepatic mRNA expression of CETP with Clec4f, Vsig4 and Ly6C were performed, and the goodness of fit R ² from linear regression analyses were shown (D). For (A through C) data are presented as means±SEM (0, 4, and 48 hours group: n=7; 8 hours group: n=8); *P<0.05, **P<0.01, ***P<0.001 as compared with the 0‐hour group. CETP indicates cholesteryl ester transfer protein; Clec4f, C‐type lectin domain family 4; Il‐1β, interleukin‐1β; LPS, lipopolysaccharide; Ly6C, lymphocyte antigen 6 complex locus C; Mcp‐1, monocyte chemotactic protein‐1; Tnfa, tumor necrosis factor α; Vsig4, V‐set and immunoglobulin domain containing 4.