Table 3.

Secondary End Points: Biochemical Parameters

	CR Group (n=36)	Control Group (n=40)	P Value
CK, day 0, U/L	98 (64–145)	83 (55–129)	0.28
Δ CK, day 0 to 24 h after cross‐clamping, U/L	596 (440–779)	539 (347–839)	0.39
LDH, day 0, U/L	207 (185–238)	220 (194–230)	0.46
Δ LDH, day 0 to 24 h after cross‐clamping, ng/L	107 (65–145)	100 (37–172)	0.92
NT‐proBNP, day 0, ng/L	576 (268–1782)	827 (438–1708)	0.25
Δ NT‐proBNP, day 0 to 24 h after cross‐clamping, ng/L	924 (340–4359)	381 (−304 to 2295)	0.27
CRP, day 0, mg/L	3.0 (3.0–3.2)	3.0 (3.0–4.6)	0.44
Δ CRP, day 0 to 24 h after cross‐clamping, mg/L	104 (82–130)	97 (73–124)	0.51
WBC, day 0, ×1E9/L	6.2 (4.9–6.8)	6.4 (4.9–7.4)	0.57
Δ WBC, day 0 to 24 h after cross‐clamping, ×109/L	3.2 (1.5–5.2)	3.8 (1.9–5.5)	0.39
Lactate, day 0, mmol/L	1.1 (1.0–1.6)	1.2 (1.0–1.6)	0.85
Δ Lactate, day 0 to 24 h after cross‐clamping, mmol/L	0.4 (0.0–0.6)	0.5 (0.1–1.5)	0.27
NSE, day 0, μmol/L	23.8 (20.1–28.3)	22.9 (19.8–29.5)	0.66
Δ NSE, day 0 to 24 h after cross‐clamping, μmol/L	5.7 (−1.6 to 12.5)	10.9 (0.5–19.4)	0.26
Troponin T, day 0, μg/L	0.013 (0.010–0.024)	0.019 (0.012–0.035)	0.045
Δ Troponin T, day 0 to 24 h after cross‐clamping, μg/L	0.558 (0.201–1.065)	0.458 (0.343–0.790)	0.85
NGAL in urine, day 0, μmol/L	17.8 (10.0–32.9)	13.8 (10.0–26.3)	0.41
Δ NGAL in urine, day 0 to 8 h after cross‐clamping, μmol/L	17.4 (−3.9 to 48.4)	9.6 (−2.5 to 30.4)	0.56
Creatinine at discharge, mg/dL	1.0 (0.9–1.3)	1.2 (1.0–1.4)	0.24
Δ Creatinine, day 0 to discharge, mg/dL	−0.08 (−0.18 to 0.04)	0.07 (−0.02 to 0.26)	0.0006

Parameters measured in serum unless otherwise indicated. Day 0 indicates baseline value before surgery. Values presented as median (interquartile range). CK indicates creatine kinase; CR, calorie restriction; CRP, C‐reactive protein; LDH, lactate dehydrogenase; NGAL, neutrophil gelatinase–associated lipocalin; NSE, neuron‐specific enolase; NT‐proBNP, N‐terminal pro‐b‐type natriuretic peptide; WBC, white blood cell count.