Skip to main content
. 2018 Mar 29;7(7):e007928. doi: 10.1161/JAHA.117.007928

Figure 1.

Figure 1

A, Representative echocardiography indicating that increasing the right ventricular (RV) pressure load induces RV dilatation, septal flattening, and left ventricular (LV) compression. Septal flattening changes geometry at the septal hinge‐point regions and LV. Short‐axis view obtained at the papillary muscle level at end systole and end diastole in a sham (A) and Pulmonary Arterial Hypertension (PAH) (B) rat. The sham rat shows a circular LV with normal round interventricular septal curvature and position throughout the cardiac cycle; in PAH, the RV is markedly enlarged and the LV is flattened and “D shaped” throughout the cardiac cycle, with the interventricular septum displaced leftward in systole and flattened into end diastole. B, Kaplan‐Meier survival curves in sham (n=8) and pulmonary artery banding (PAB) (n=26) at 6 weeks in rats. The median survival in PAB is 6. P<0.005 vs sham. Echocardiographic parameters are summarized in table 1.