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. 2018 Mar 29;7(7):e007928. doi: 10.1161/JAHA.117.007928

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© 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Application of pulmonary artery banding (PAB) induces a diverse upregulation in activity of the integrin‐dependent signals that consequently trigger profibrotic pathway 6 weeks after sham and PAB procedures. A, Representative Western blots detecting basic regional expression of protein levels and phosphorylation rates of the integrin‐induced downstream signaling pathway components (focal adhesion kinase [FAK], integrin‐linked kinase [ILK], and extracellular signal–regulated kinase [ERK]). Values are expressed as medians and interquartile range (n=5). ^* P<0.05, ^** P<0.001 vs sham. B, Representative Western blots detecting basic regional expression of protein levels and phosphorylation rates of profibrotic components transforming growth factor (TGF)‐β1, Smad 2, Smad 3, and connective tissue growth factor (CTGF) in sham and PAB‐exposed hearts. Quantification analyses (n=5). Values are expressed as medians and interquartile range. *P<0.05, **P<0.001 vs sham; . HP indicates hinge point; LV, left ventricle; and RV, right ventricle.