Table 1.

Comparison of Echocardiographic Measurements in PAB Rats Versus Shams

Variables	Sham Group (n=8)	PAB Group (n=5)
HR, bpm
Median	341.1	264*
Interquartile range	320.4–373.4	244.5–346.5
RV parameter
RVEDD, cm
Median	0.25	0.54†
Interquartile range	0.24–0.2625	0.515–0.62
RVESD, cm
Median	0.155	0.49†
Interquartile range	0.12–0.19	0.37–0.515
RV FAC, %
Median	44	21†
Interquartile range	37.5–47	18–22
TAPSE, cm
Median	0.28	0.09†
Interquartile range	0.2425–0.3075	0.065–0.155
RV‐MPI
Median	0.13	0.59†
Interquartile range	0.02–0.31	0.475–0.645
LV parameter
LV end‐systolic ECC
Median	1.095	2.22
Interquartile range	1.06–1.163	0.73–2.545
LV end‐diastolic ECC
Median	1.065	1.57
Interquartile range	1.045–1.113	1.075–1.585
LVPW, cm
Median	0.15	0.11
Interquartile range	0.13–0.17	0.09–0.145
IVS, cm
Median	0.135	0.13
Interquartile range	0.1275–0.1525	0.085–0.155
LVEDD, cm
Median	0.885	0.71
Interquartile range	0.7175–0.6225	0.645–0.92
LVESD, cm
Median	0.55	0.61
Interquartile range	0.485–0.66	0.385–0.645
LV SF, %
Median	33.5	28
Interquartile range	27–39	20–42

Quantification of the echocardiograms and presented as the LV eccentricity index. These geometrical LV changes are expected to induce increased mechanical stress at the RV and septal hinge‐point regions and mimic findings in human RV hypertension. Two‐dimensional measurements: ECC and FAC. M‐mode measurements: PW, SF, and TAPSE. Pulsed‐Doppler measurement: MPI. Bpm indicates beats per minute; ECC, eccentricity index; FAC, fractional area change; HR, heart rate; IVS, interventricular septum; LV, left ventricle; LVEDD, LV end‐diastolic diameter; LVESD, LV end‐systolic diameter; MPI, myocardial performance index; PAB, pulmonary artery band; PW, posterior wall; RV, right ventricle; RVEDD, RV end‐diastolic diameter; RVESD, RV end‐systolic diameter; SF, shortening fraction; TAPSE, tricuspid systolic annular excursion.

*P<0.05 vs sham.

^† P<0.01 vs shams.