. 2018 Mar 8;9(7):1135–1144. doi: 10.7150/jca.22546

Table 4.

Multivariate analysis of ESCC patients' DFS

Variables	5-year DFS				9-year DFS
Variables	HR	95%CI		P value	HR	95%CI		P value
Tumor size				0.066				0.060
<3cm	Reference				Reference
≥3cm	0.712	0.496	1.023	0.066	0.716	0.505	1.014	0.060
Tumor depth				0.456				0.505
T1	Reference				Reference
T2	0.772	0.273	2.180	0.625	0.616	0.217	1.750	0.364
T3+4	0.721	0.430	1.208	0.214	0.797	0.494	1.286	0.352
Lymph node metastasis				0.007				0.016
0	Reference				Reference
≥1	0.354	0.165	0.757	0.007	0.407	0.196	0.843	0.016
TNM stage				0.997				0.937
ⅠA+ⅠB	Reference				Reference
ⅡA+ⅡB	0.942	0.204	4.341	0.939	0.967	0.232	4.035	0.963
ⅢA+ⅢB+ⅢC	0.986	0.454	2.144	0.972	0.890	0.420	1.886	0.762
Histological grade				0.017				0.035
Ⅰ	Reference				Reference
Ⅱ	0.000	0.000	2.76×10²⁰¹	0.961	0.000	0.000	3.07×10¹⁸⁰	0.956
Ⅲ	0.588	0.413	0.408	0.004	0.632	0.447	0.895	0.010
eIF3e expression				0.704				0.456
Low	Reference				Reference
High	0.866	0.412	1.819	0.704	0.755	0.361	1.581	0.456

^a Bold values indicate statistical significance (p < 0.05).

Abbreviation: ESCC: Esophageal squamous cell carcinoma; DFS: disease free survival; HR: hazard ratio; CI: confidence interval; eIF3e: Eukaryotic translation initiation factors 3e.