Table 1.
Characteristics of patients with non-metastatic gastric cancer by age, young versus elderly. SEER 2004-2012 (n=12216)a
| Characteristics | Total | <50 | ≥50 | P valueb |
|---|---|---|---|---|
| 12216 (100) | 1338 (10.95) | 10878 (89.05) | ||
| Median Follow-up | ||||
| Months (IQR) | 16 (6-42) | 21 (9-48) | 16 (5-41) | |
| Age (IQR) | 70 (59-79) | 44 (39-47) | 73 (64-80) | |
| Sex | 0.01 | |||
| Male | 6793 (55.61) | 700 (52.32) | 6093 (56.01) | |
| Female | 5423 (44.39) | 638 (47.68) | 4785 (43.99) | |
| Race | 0.001 | |||
| White | 7254 (59.38) | 762 (56.95) | 6492 (59.68) | |
| Black | 2014 (16.49) | 272 (20.33) | 1742 (16.01) | |
| American Indian/Alaska Native | 115 (0.94) | 17 (1.27) | 98 (0.9) | |
| Asian or Pacific Islander | 2792 (22.86) | 283 (21.15) | 2509 (23.06) | |
| Unknown | 41 (0.34) | 4 (0.3) | 37 (0.34) | |
| Marital status | <0.001 | |||
| Married | 7094 (58.07) | 863 (64.5) | 6231 (57.28) | |
| Single (never married) | 1658 (13.57) | 350 (26.16) | 1308 (12.02) | |
| Divorced/Separated | 1079 (8.83) | 116 (8.67) | 963 (8.85) | |
| Widowed | 2385 (19.52) | 9 (0.67) | 2376 (21.84) | |
| Histological type | <0.001 | |||
| Adenocarcinoma, NOS | 5852 (47.9) | 443 (33.11) | 5409 (49.72) | |
| Adenocarcinoma, intestinal type | 2042 (16.72) | 84 (6.28) | 1958 (18) | |
| Carcinoma, diffuse type | 803 (6.57) | 145 (10.84) | 658 (6.05) | |
| Tubular adenocarcinoma | 148 (1.21) | 6 (0.45) | 142 (1.31) | |
| Papillary adenocarcinoma, NOS | 39 (0.32) | 5 (0.37) | 34 (0.31) | |
| Mucinous adenocarcinoma | 233 (1.91) | 24 (1.79) | 209 (1.92) | |
| Signet ring cell carcinoma | 3099 (25.37) | 631 (47.16) | 2468 (22.69) | |
| Site | 0.046 | |||
| Fundus of stomach | 573 (4.69) | 52 (3.89) | 521 (4.79) | |
| Body of stomach | 1493 (12.22) | 150 (11.21) | 1343 (12.35) | |
| Gastric antrum | 4235 (34.67) | 442 (33.03) | 3793 (34.87) | |
| Pylorus | 678 (5.55) | 73 (5.46) | 605 (5.56) | |
| Lesser curvature of stomach, NOS | 1768 (14.47) | 189 (14.13) | 1579 (14.52) | |
| Greater curvature of stomach, NOS | 722 (5.91) | 86 (6.43) | 636 (5.85) | |
| Overlapping lesion of stomach | 1178 (9.64) | 158 (11.81) | 1020 (9.38) | |
| Stomach, NOS | 1569 (12.84) | 188 (14.05) | 1381 (12.7) | |
| Stagec | <0.001 | |||
| I | 4453 (36.45) | 342 (25.56) | 4111 (37.79) | |
| II | 3708 (30.35) | 432 (32.29) | 3276 (30.12) | |
| III | 4055 (33.19) | 564 (42.15) | 3491 (32.09) | |
| Depth of invasion | <0.001 | |||
| T1 | 3765 (30.82) | 287 (21.45) | 3478 (31.97) | |
| T2 | 1446 (11.84) | 143 (10.69) | 1303 (11.98) | |
| T3 | 5736 (46.95) | 733 (54.78) | 5003 (45.99) | |
| T4 | 1269 (10.39) | 175 (13.08) | 1094 (10.06) | |
| Lymph node involvement | <0.001 | |||
| N0 | 6071 (49.7) | 528 (39.46) | 5543 (50.96) | |
| N1 | 1670 (13.67) | 193 (14.42) | 1477 (13.58) | |
| N2 | 2250 (18.42) | 295 (22.05) | 1955 (17.97) | |
| N3 | 2225 (18.21) | 322 (24.07) | 1903 (17.49) | |
| Grade | <0.001 | |||
| Grade I | 534 (4) | 25 (1.87) | 509 (4.68) | |
| Grade II | 2940 (24.07) | 129 (9.64) | 2811 (25.84) | |
| Grade III | 7538 (61.71) | 1038 (77.58) | 6500 (59.75) | |
| Grade IV | 253 (2.07) | 38 (2.84) | 215 (1.98) | |
| Cell type not determined | 951 (7.78) | 108 (8.07) | 843 (7.75) | |
| Surgery | <0.001 | |||
| No surgery | 2332 (19.09) | 204 (15.25) | 2128 (19.56) | |
| Non-Total or Non-near-total gastrectomy | 7780 (63.69) | 799 (59.72) | 6981 (64.18) | |
| Total or near total gastrectomy | 2104 (17.22) | 335 (25.04) | 1769 (16.26) | |
| Radiotherapy | <0.001 | |||
| No radiotherapy | 8692 (71) | 750 (56.05) | 7942 (73) | |
| Radiotherapy | 3322 (27.19) | 563 (42.08) | 2759 (25.36) | |
| Radiotherapy unknown | 202 (1.65) | 25 (1.87) | 177 (1.63) | |
Abbreviation: NOS= no other specific; SEER=Surveillance, Epidemiology and End Results; IQR=interquartile range
aData are presented as No. (Percentage) of patients.
bP value of the Chi-square test or Wilcoxon-Mann-Whitney test comparing young and elderly groups
cBeing restaged according to the criteria of AJCC Cancer Staging Manual (7th edition, 2010)