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The expression of VDAC1 is upregulated in CRC tissue and cell lines. A, VDAC1 mRNA and protein is upregulated in CRC cell lines. B, VDAC1 mRNA highly expressed in CRC tissues and negatively associated with corresponding miR-490-3p expression levels. C, high expression of VDAC1 mRNA in CRC based on individual cancer stages were obtained from TCGA samples. D, representative immunohistochemical staining for VDAC1 from CRC tissues and matched ANTs. * P < 0.05, **P < 0.01, ***P < 0.001.
