Figure 2.

Impact of E6 and E7 oncogenes in Wnt signaling. A) The binding of E6 and Dvl can block the degradation of β-catenin and enhance TCF transcriptional activity. B) E6 and E7 bind to the catalytic subunit of PP2A to inhibit its activity and subsequently contribute to β-catenin stabilization in the cytoplasm. C) E6/E6AP can protect β-catenin from degradation. D) E6 induces MZF1 expression and consequently activates NKX2-1 transcription before promoting FOXM1 expression. FOXM1 can then induce β-catenin nuclear translocation. E) E6 and E7 upregulate β-catenin expression and enhance TCF-mediated transcription; this is attributed to the decrease in Siah-1 protein.