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. 2018 Apr 13;12:707–717. doi: 10.2147/OPTH.S150816

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© 2018 Thygesen. This work is published and licensed by Dove Medical Press Limited

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Tear film disruption caused by instillation of a single drop of BAK (0.01%).

Notes: Sixteen healthy volunteers, pretreated with a local anesthetic, received two drops of BAK or saline. The time until the appearance of focal or generalized drying was measured. Adapted by permission from BMJ Publishing Group Ltd. Effect of benzalkonium chloride on the stability of the precorneal tear film in rabbit and man, Wilson WS, Duncan AJ, Jay JL, British Journal of Ophthalmology. 59(11):667–669. © 1975.¹⁹

Abbreviation: BAK, benzalkonium chloride.