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. 2018 Apr 13;12:707–717. doi: 10.2147/OPTH.S150816

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© 2018 Thygesen. This work is published and licensed by Dove Medical Press Limited

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Reduction in clinical signs following switch from preservative-added to preservative-free eye drops.

Notes: In an open, prospective clinical trial, 435 glaucoma patients were switched from their previous preservative-added timolol medication to a preservative-free timolol preparation. Clinical signs were recorded during 84 days of treatment (*p<0.01, **p<0.05). Reproduced from Bron A, Chiambaretta F, Pouliquen P, Rigal D, Rouland JF. Efficacy and safety of substituting a twice-daily regimen of timolol with a single daily instillation of nonpreserved beta-blocker in patients with chronic glaucoma or ocular hypertension. Français D’Ophtalmologie 2003; volume 26, issue 7:pages 668–674. Copyright © 2003, Elsevier Masson SAS. All rights reserved.²⁶