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. 2018 Feb 22;61(5):2052–2061. doi: 10.1021/acs.jmedchem.7b01837

Figure 1.

Figure 1

Chemical structures and general scheme for the synthesis of the reported agents. (A) Chemical structures of the YSA peptide, 123B9, and of the derivatized paclitaxel used for the conjugation. (B) General scheme for the synthesis of the (123B9)2-motif. Regents and conditions: (1) NH2NH2, DMF, room temperature (rt), 30 min; (2) 5-hexynoic acid, HTBU, HOBt, DIEPA, DMF, rt, 12 h; (3) TFA, phenol, TIPS, water, rt, 3 h. (C) Chemical structure of (123B9)2–L2–PTX. The L2 linker is highlighted by squared parentheses.