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. 2018 Feb 22;61(5):2052–2061. doi: 10.1021/acs.jmedchem.7b01837

Figure 4.

Figure 4

CTC evaluation using an orthotopic breast-cancer mouse metastatic model. CTC enumeration studies were done using NanoVelcro CTC Chips. (A) CTC counts in MDA-MB-231 breast-cancer cells orthotopically grafted into NOD-SCID mice treated with (123B9)2–L2–PTX or Abraxane (ABX). The CTC counts in the (123B9)2–L2–PTX group were significantly lower. (B) Captured cells directly stained for pan-cytokeratin (green) and CD45 (red) expression. (C) Pan-cytokeratin-expressing cells histologically evaluated as cancer. The cell clusters captured were elevated in the Abraxane-treated mice (D) compared with those from the (123B9)2–L2–PTX-treated mice (E). In panels B–E, the scale bars represent 10 μm.