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. 2018 Feb 22;61(5):2052–2061. doi: 10.1021/acs.jmedchem.7b01837

Figure 5.

Figure 5

Syngeneic breast-cancer metastasis model. 4T1 cells were introduced to BALB/c mice by intracardiac injections and treated with (123B9)2–L2–PTX or Abraxane. (A) Gross lung metastasis observed in the control, Abraxane, and (123B9)2–L2–PTX groups. (B) Metastasis to the left lung superior lobe quantitated under the microscope (*P < 0.05, ***P < 0.001). (C) Histochemistry on lung sections from the three groups demonstrating the tumors (H&E at 4× magnification) and the vascularization by CD31 immuno-localization (40× magnification).