Table 1.
Clinicopathologic characteristics based on presence of jaundice
| PREOPERATIVE CHARACTERISTICS | No Jaundice (n=218) |
Jaundice (n=33) |
P value |
|---|---|---|---|
|
| |||
| Age (median, IQR) | 67.3 (56.3–73.8) | 64.2 (56.3–69.5) | 0.1575 |
|
| |||
| Male Gender | 73 (33.3) | 9 (27.3) | 0.612 |
|
| |||
| Race (n=241) | |||
| White | 150 (71.8) | 26 (81.3) | 0.552 |
| Black | 29 (13.9) | 1 (3.1) | |
| Asian | 15 (7.1) | 3 (9.4) | |
| Latino | 10 (5.8) | 2 (6.3) | |
| Other | 5 (2.4) | 0 (0) | |
|
| |||
| ASA Class > 3 (n=177) | 87 (57.6) | 16 (61.5) | 0.83 |
|
| |||
| HTN (n=224) | 119 (60.4) | 14 (51.9) | 0.41 |
|
| |||
| Diabetes (n=224) | 49 (24.8) | 1 (3.7) | 0.012 |
|
| |||
| Prior Cardiac Event (n=224) | 25 (12.7) | 0 (0) | 0.051 |
|
| |||
| CHF (n=224) | 8 (4.1) | 1(3.7) | 1.000 |
|
| |||
| Smoking history (n=224) | 32 (16.2) | 8 (29.6) | 0.089 |
|
| |||
| COPD (n=224) | 6 (3.0) | 1 (3.7) | 0.598 |
|
| |||
| Preoperative Sepsis | 3 (1.4) | 1 (1.3) | 0.424 |
|
| |||
| Peak Bilirubin (mg/dL) | 0.6 (0.4–0.9) | 9.55 (4.2–15.9) | <0.001 |
|
| |||
| Last bilirubin (mg/dL) | 0.5 (0.4–0.7) | 1.5 (0.75–2.85) | <0.001 |
|
| |||
| Creatinine (mg/dL) | 0.8 (0.8–1) | 0.8 (0.7–0.9) | 0.0754 |
|
| |||
| Albumin (g/L) | 3.9 (3.5–4.3) | 3.3 (2.7–3.6) | <0.0001 |
|
| |||
| CA19-9 | 15 (11–32) | 187 (25–941) | 0.0005 |
|
| |||
| Preoperative Biliary intervention | |||
| None | 212 (98.6) | 8 (24.2) | <0.001 |
| Endoscopic | 3 (1.4) | 16 (48.5) | |
| Percutaneous | 0 (0) | 6 (18.2) | |
| Both | 0 (0) | 3 (9.1) | |
|
| |||
| Neoadjuvant chemotherapy (n=247) | 8 (3.7) | 2 (6.3) | 0.623 |
|
| |||
| Neoadjuvant radiotherapy (n=242) | 3 (1.4) | 0 (0) | 1.000 |
|
| |||
| OPERATIVE RESULTS | |||
|
| |||
| CBD resection | 64 (29.8) | 29 (87.9) | <0.001 |
|
| |||
| Extent of resection | |||
| Simple cholecystectomy | 21 (9.6) | 3 (9.1) | <0.001 |
| Radical cholecystectomy (Segments 4b/5) | 182 (83.5) | 17 (51.5) | |
| Trisectionectomy | 15 (6.9) | 13 (39.4) | |
|
| |||
| Portal Vein Resection | 1 (0.46) | 4 (12.1) | <0.001 |
|
| |||
| PATHOLOGY | |||
|
| |||
| R1 margins (vs. R0) | 19 (8.8) | 16 (48.5) | <0.001 |
|
| |||
| Grade (n=213) | |||
| Low | 23 (12.6) | 2 (6.7) | 0.349 |
| Moderate | 97 (53) | 20 (66.7) | |
| Poor | 63 (34.4) | 8 (26.7) | |
|
| |||
| AJCC Stage | |||
| I | 19 (9.3) | 0 (0) | 0.072 |
| II | 64 (31.2) | 5 (16.1) | |
| IIIA | 38 (18.5) | 8(25.8) | |
| IIIB | 63 (30.7) | 15 (48.4) | |
| IV* | 21 (10.2) | 3 (9.7) | |
|
| |||
| T-stage | |||
| T1 | 21 (10.2) | 0 (0) | 0.005 |
| T2 | 98 (47.8) | 8 (25.5) | |
| T3 | 73 (35.6) | 20 (64.5) | |
| T4 | 13 (6.3) | 3 (9.7) | |
|
| |||
| N-stage | |||
| N0 | 113 (51.8) | 10 (30.3) | 0.026 |
| N1 | 71 (32.6) | 19 (57.6) | |
| N2 | 11 (5) | 0 (0) | |
| Nx | 23 (10.6) | 4 (12.1) | |
|
| |||
| Papillary variant (n=86) | 17 (22.7) | 4 (36.4) | 0.451 |
|
| |||
| PNI (n=142) | 60 (50.4) | 20 (87) | 0.001 |
|
| |||
| LVI (n=141) | 48 (41) | 17 (70.8) | 0.012 |
Abbreviations: LVI= lymphovascular invasion; PNI= perineural invasion; AJCC= American Joint Commission on Cancer; CBD= common bile duct; COPD= chronic obstructive pulmonary disease; CHF= congestive heart failure; HTN= hypertension; ASA=American Society of Anesthesiologist; IQR= interquartile range
*
Stage IV includes M0 patients with T1-3N2 and T4N0-2 disease.