Table 2.

The regulations of ELF4.

Regulation	Regulatory factors	Effect	References
Transcription	SP1	Activation	Koga et al. (2005)
Transcription	E2F1	Activation	Taura et al. (2011)
Transcription	HIF-1α	Activation	Suico et al. (2016)
Transcription/enhancer	PU.1, FLI-1, ERG	Activation	Smith et al. (2012)
Transcription	GFI1B	Repression	Smith et al. (2012)
Phosphorylation	CYCLIN A/CDK2	Restriction of ELF4 activity to G1 phase	Miyazaki et al. (2001)
Phosphorylation	ATM kinase	Protein degradation	Sashida et al. (2011)
Phosphorylation	TBK1	Activation	You et al. (2013)
Phosphorylation	MKK4/JNK1	Activation	Kim et al. (2011)
Ubiquitination	SCF/SKP2	Protein degradation	Liu et al. (2006)
Ubiquitination	MDM2	Protein degradation	Suico et al. (2014)
SUMOylation	SUMO-1/-2	Repression	Suico et al. (2006)
Interactions/fusions	Partners
Protein interaction	PML	Activation	Suico et al. (2004a, b)
Protein interaction	STING	Activation	You et al. (2013)
Protein interaction	RUNX2	Repression, activation	Kim et al. (2007), Lee et al. (2010)
Protein interaction	AML1B	Activation	Mao et al. (1999)
Protein interaction	AML1/ETO fusion protein	Repression	Mao et al. (1999)
Protein interaction	Wild-type and mutant nucleophosmin	Repression and activation, respectively	Ando et al. (2013)
Translocation/fusion	ERG	Not determined	Moore et al. (2006)
Inversion/fusion	BCORL1	Repression	Totoki et al. (2011)