Figure 1.

Schematic representation of KLF functional domains and gene regulation. (A) The transactivation and transrepression domains are located at the N-terminus of KLF proteins. Three consecutive zinc finger motifs are located at the C-terminus. (B) Diagram illustrating the regulatory patterns for KLFs in gene transcription. KLFs induce or repress gene expression in cooperation with co-activators or co-repressors or through interaction with other specific transcription factors. TF, transcription factor; CBP, CREB-binding protein; PCAF, p300/CBP-associated factor; HDACs, histone deacetylases; CtBP, C-terminal-binding protein; Sin3A, SIN3 transcription regulator family member A.