Table 2.
Univariate and multivariate Cox proportional hazard model of GC with overall survival
| Parameters | Univariate analysis
|
Multivariate analysis
|
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age (years) | ||||
| <60 (ref) | 1 | <0.001 | 1 | <0.001 |
| ≥60 | 1.408 (1.188–1.668) | 1.363 (1.146–1.620) | ||
| Sex | ||||
| Male (ref) | 1 | 0.994 | ||
| Female | 0.999 (0.831–1.202) | |||
| Blood type | ||||
| A (ref) | 1 | |||
| B | 1.002 (0.79–1.271) | 0.989 | ||
| O | 1.010 (0.819–1.245) | 0.928 | ||
| AB | 1.143 (0.806–1.622) | 0.454 | ||
| Tumor location | ||||
| Lower third (ref) | 1 | 1 | ||
| Upper third | 1.691 (1.414–2.023) | <0.001 | 1.43 (1.18–1.72) | <0.001 |
| Full third | 4.556 (3.203–6.48) | <0.001 | 2.7 (1.89–3.85) | <0.001 |
| Tumor size (cm) | ||||
| <5 (ref) | 1 | <0.001 | ||
| ≥5 | 1.86 (1.567–2.207) | |||
| Differentiation | ||||
| Well/moderate (ref) | 1 | <0.001 | 1 | <0.001 |
| Poor/others | 1.808 (1.393–2.348) | 1.75 (1.34–2.28) | ||
| TNM stage | ||||
| I (ref) | 1 | 1 | ||
| II | 2.832 (1.562–5.137) | <0.001 | 2.481 (1.365–4.51) | 0.003 |
| III | 12.636 (7.409–21.552) | <0.001 | 10.66 (6.23–18.45) | <0.001 |
| IV | 35.023 (19.784–61.999) | <0.001 | 29.75 (16.74–52.87) | <0.001 |
| TG (mM) | ||||
| <1.9 | 1 | 0.005 | ||
| ≥1.9 | 0.656 (0.488–0.882) | |||
| CHO (mM) | ||||
| <4.1 | 1 | 0.09 | ||
| ≥4.1 | 0.834 (0.676–1.029) | |||
| HDL-C (mM) | ||||
| <1.2 | 1 | 0.13 | ||
| ≥1.2 | 0.873 (0.731–1.041) | |||
| LDL-C (mM) | ||||
| <3.1 | 1 | 0.366 | ||
| ≥3.1 | 1.082 (0.912–1.283) | |||
| ApoA1 (mM) | ||||
| <1.4 | 1 | 0.004 | ||
| ≥1.4 | 0.717 (0.572–0.9) | |||
| ApoB (mM) | ||||
| <1 | 1 | 0.042 | ||
| ≥1 | 1.194 (1.006–1.417) | |||
| LDL-C/HDL-C ratio | ||||
| <2.9 | 1 | 0.044 | ||
| ≥2.9 | 1.191 (1.005–1.411) | |||
| ApoB/ApoA1 ratio | ||||
| <1 | 1 | 0.001 | 1 | 0.002 |
| ≥1 | 1.382 (1.133–1.685) | 1.373 (1.123–1.68) | ||
Note: The bold values denote statistical significance (P<0.05).
Abbreviations: ApoA1, Apolipoprotein A1; ApoB, Apolipoprotein B; CHO, cholesterol; CI, confidence interval; GC, gastric cancer; HDL-C, high-density lipoprotein-cholesterol; HR, hazard ratio; LDL-C, low-density lipoprotein-cholesterol; TG, triglycerides; TNM, tumor–node–metastasis.